The first large randomised controlled trial of lipoedema surgery. After 12 months, 68% of the women who had liposuction reached a meaningful reduction in leg pain, compared with 8% of those on conservative therapy alone, and the result held across all three stages. It has already changed policy in Germany, where statutory health insurance now covers surgery for eligible patients.
The Lancet | September 2026 (Podda et al.)Lipoedema Research Library
The lipoedema research pool is shallow. But there's important work in progress by talented and passionate researchers around the world so stay tuned. Here you'll find hundreds of hours of research, refined and collated for you.
Links to the papers, useful websites, video content, Standards of Care and resources that have given me the most clarity, and real actionable insights. It's not everything, but it will get you on the path to mastering your lipoedema.
New
What's New
This is where I put the newest research that changes how we understand or manage lipoedema. At the moment it's the LIPLEG trial, the first large randomised controlled trial of lipoedema surgery, and I'd argue it's the most important study published on lipoedema to date.
My write-up of what the trial actually found, what it does and does not prove, and what it could mean for getting surgery funded here in Australia.
From the blogThe pathophysiology story so far

Karen Herbst explains in plain language what lipoedema is, how it differs from lymphoedema and obesity, and why it is so often missed.
Dr Karen Herbst for Lympha Press 2024Treats fascia as a signalling system rather than packing material, which is the mechanism behind why fascial and compression work eases lipoedema pain.
J Barclay, A Slater, R Granfar, R Pratt — Frontiers in Neurology 2024The compartment syndrome theory of lipoedema, explained clearly by the endocrinologist who has researched it most.
Dr Karen Herbst for Lympha Press 2023A clinician-level overview of current pathophysiology and the newer therapeutic options in one sitting.
Medical Online Hub 2022An Australian news summary of the research breakthroughs behind the lipoedema blood test work.
Aged Care News 2021Stanford's discovery of a lipoedema biomarker in lymph fluid, the kind of laboratory finding that changes how diagnosis is approached.
Stanford Medicine 2020Nutrition & Diet

Five documented cases managed without surgery, including the conservative protocols that were used.
American Journal of Case Reports 2021Chuck Ehrlich explains the anti-inflammatory eating approach he uses alongside lymphatic treatment.
Chuck Erhlick, MS, MBA 2019Clinician-led guidance on supplements, including which ones are worth trying and which are not.
Dr Karen Herbst & Chuck Erhlich 2017A practical comparison of the main anti-inflammatory diets used in lipoedema.
Lipedema.netA peer-reviewed review of the supplement evidence, useful for checking a claim before you spend money on it.
Journal of Preventative Medicine and Hygiene 2022Dr Herbst's own supplement protocol for lipoedema and related conditions.
Dr Karen HerbstA broad, plain-English treatment overview from an established patient-led research foundation.
The Lipedema ProjectExplains the food and oestrogen link that sits behind so many lipoedema flare-up questions.
Healthline 2020Shockwave and Ultrasound Cavitation

Peer-reviewed findings on shockwave and deep oscillation treatment for lipoedema.
Journal of Aesthetic Nursing 2024Karen Ashforth's conference session on ultrasound cavitation and shockwave therapy as conservative options.
Karen Ashforth at Lipedema World Congress 2024How to recognise fibrotic tissue in lipoedema and, more importantly, what actually shifts it.
Karen Ashforth for Lympha Press 2023A pilot study comparing three commonly sold non-surgical treatments, with measured outcomes.
Lymphology 2023Lymphatics, Compression and MLD

A clear walkthrough of inflamed tissue and nodules in lipoedema, and what they mean for treatment.
Karen Ashforth, OT MS CLT-LANA — LE&RN 2019A well-cited academic review of lipoedema that is worth reading in full to understand the disease as a whole.
Biomedicines 2022Trial data on what compression therapy actually changes, and how consistently it is worn in real life.
Int J Environ Res Public Health 2022A practical guide to choosing compression garments, including flat-knit options.
Lipedema.netStep-by-step self manual lymph drainage you can follow at home.
Lipedema.netA downloadable, therapist-written guide to daily self-care.
Talk LipoedemaMast Cell Activation & Histamine Intolerance

A small but specific paper on treating the mast-cell side of lipoedema.
La Clinica Therapeutica 2023Flags the triggers and co-conditions that quietly make symptoms worse.
Lympha PressA symptom checklist for histamine intolerance, useful if you suspect the pattern but cannot name it.
White Hart ClinicExplains why hormonal shifts change histamine symptoms, which is why flares follow your cycle.
FX MedicineAn Australian pathology laboratory's low-histamine diet, a sensible starting reference before trialling it.
Sullivan Nicolaides PathologyPulls the oestrogen, histamine and mast cell triangle into one readable summary.
Genetic LifehacksSkin Health
Nursing-focused guidance on diagnosis and day-to-day skin care.
Mark Allen PublishingA simple home moisturiser recipe plus dry brushing technique.
Lipoedema LadiesA physiotherapist demonstrating dry brushing, which is the easiest way to copy the technique correctly.
Cancer Rehab PTStandards of Care
'Standard of care' documents are a great tool to help you build your lipoedema action plan. These are a medical treatment guideline, that specify the ideal treatment for a particular condition, based on scientific evidence and collaboration between medical professionals involved in the treatment of the condition. I couldn't find one for Australia which is disappointing, but these UK, USA, Germany and Dutch guidelines are very helpful.
For Physicians and Clinicians
If you're looking for resources to help you diagnose and manage your lipoedema patients, you could start with the Standards of Care section, and a few more resources below. Unfortunately I could only find one solid Australian resource (Praxhub module), but the other USA-originating resources are all fantastic.
Comorbidities
I found plenty of information regarding comorbid conditions such as venous insufficiency, hypermobility and Ehlers Danlos, muscle weakness and gait irregularities, although more research is clearly needed. All are of personal interest to me, so I'll add to this collection if I find anything new.





