Lipoedema Research Library

The lipoedema research pool is shallow. But there's important work in progress by talented and passionate researchers around the world so stay tuned. Here you'll find hundreds of hours of research, refined and collated for you.

Links to the papers, useful websites, video content, Standards of Care and resources that have given me the most clarity, and real actionable insights. It's not everything, but it will get you on the path to mastering your lipoedema.

New

What's New

This is where I put the newest research that changes how we understand or manage lipoedema. At the moment it's the LIPLEG trial, the first large randomised controlled trial of lipoedema surgery, and I'd argue it's the most important study published on lipoedema to date.

Liposuction versus conservative therapy for patients with lipoedema (LIPLEG): a multicentre, randomised, controlled trial

The first large randomised controlled trial of lipoedema surgery. After 12 months, 68% of the women who had liposuction reached a meaningful reduction in leg pain, compared with 8% of those on conservative therapy alone, and the result held across all three stages. It has already changed policy in Germany, where statutory health insurance now covers surgery for eligible patients.

The Lancet | September 2026 (Podda et al.)
01

The pathophysiology story so far

Line illustration of tissue structure
Fascia as a regulatory system in health and disease

Treats fascia as a signalling system rather than packing material, which is the mechanism behind why fascial and compression work eases lipoedema pain.

J Barclay, A Slater, R Granfar, R Pratt — Frontiers in Neurology 2024
02

Nutrition & Diet

Line illustration of nutritious food
Dietary supplements for lipedema

A peer-reviewed review of the supplement evidence, useful for checking a claim before you spend money on it.

Journal of Preventative Medicine and Hygiene 2022
Supplement Protocol

Dr Herbst's own supplement protocol for lipoedema and related conditions.

Dr Karen Herbst
Lipedema Treatment & Causes

A broad, plain-English treatment overview from an established patient-led research foundation.

The Lipedema Project
03

Shockwave and Ultrasound Cavitation

Line illustration of shockwave waves
04

Lymphatics, Compression and MLD

Line illustration of lymphatic vessels
05

Mast Cell Activation & Histamine Intolerance

Line illustration of a mast cell
Histamine diet

An Australian pathology laboratory's low-histamine diet, a sensible starting reference before trialling it.

Sullivan Nicolaides Pathology
06

Skin Health

07

Standards of Care

'Standard of care' documents are a great tool to help you build your lipoedema action plan. These are a medical treatment guideline, that specify the ideal treatment for a particular condition, based on scientific evidence and collaboration between medical professionals involved in the treatment of the condition. I couldn't find one for Australia which is disappointing, but these UK, USA, Germany and Dutch guidelines are very helpful.

08

For Physicians and Clinicians

If you're looking for resources to help you diagnose and manage your lipoedema patients, you could start with the Standards of Care section, and a few more resources below. Unfortunately I could only find one solid Australian resource (Praxhub module), but the other USA-originating resources are all fantastic.

09

Comorbidities

I found plenty of information regarding comorbid conditions such as venous insufficiency, hypermobility and Ehlers Danlos, muscle weakness and gait irregularities, although more research is clearly needed. All are of personal interest to me, so I'll add to this collection if I find anything new.

Hypermobility and ED

Venous Insufficiency

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